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This prerequisite for hormone therapy initiation is based on the belief that in order to be able to make an informed choice about whether or not to transition change sex , a transsexual person must live in their desired gender role full time. Higher doses of estrogen, on the other hand, tend to make mood problems in cis women worse. Hormone therapy for transgender individuals has been shown in medical literature to be safe, when supervised by a qualified medical professional. Those who do take a combination of drugs to feminize themselves. After prescribing the hormones, the doctor must be able to adequately monitor their patient.

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